A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases

Table 3

KEGG pathway enrichment analysis.

KEGG pathway	Number of targets	Count
Pathways in cancer	IL6, AR, PTGS2, PDGFA, MMP9, PPARG, TP53, MMP2, TGFB1, MMP1, STAT3, AGTR1, HIF1A, VEGFA, F2R	15
Neuroactive ligand-receptor interaction	AGTR1, ADRB2, DRD2, CHRM2, LEPR, F2, ADRA1A, NR3C1, HTR2C, F2R, HTR2A	11
Proteoglycans in cancer	HIF1A, TNF, MMP9, VEGFA, ESR1, TP53, MMP2, TGFB1, STAT3	9
PI3K-Akt signaling pathway	IL4, IL6, PDGFA, CHRM2, VEGFA, TP53, NOS3, JAK3, F2R	9
Malaria	VCAM1, ICAM1, SELP, IL6, TNF, IFNG, TGFB1, IL10	8
Calcium signaling pathway	AGTR1, ADRB2, CHRM2, ADRA1A, NOS3, HTR2C, F2R, HTR2A	8
HTLV-I infection	VCAM1, ICAM1, IL6, TNF, PDGFA, TP53, JAK3, TGFB1	8
Inflammatory bowel disease (IBD)	IL4, IL6, TNF, IFNG, TGFB1, IL10, STAT3	7
Rheumatoid arthritis	ICAM1, IL6, TNF, IFNG, VEGFA, TGFB1, MMP1	7
HIF-1 signaling pathway	IL6, HIF1A, IFNG, EDN1, VEGFA, NOS3, STAT3	7
TNF signaling pathway	VCAM1, ICAM1, IL6, TNF, PTGS2, MMP9, EDN1	7
Jak-STAT signaling pathway	IL4, IL6, LEPR, IFNG, JAK3, IL10, STAT3	7
Cytokine-cytokine receptor interaction	IL4, IL6, TNF, LEPR, IFNG, TGFB1, IL10	7
African trypanosomiasis	VCAM1, ICAM1, IL6, TNF, IFNG, IL10	6
Leishmaniasis	IL4, TNF, PTGS2, IFNG, TGFB1, IL10	6