Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 3

Review Article

Efficacy and Safety of Duhuo Jisheng Decoction for Postmenopausal Osteoporosis: A Systematic Review and Meta-Analysis

Table 3

Summary of findings tables of DHJSD for PMOP.

OutcomesAnticipated absolute effects (95% CI)Relative effect (95% CI)Participants (studies)Certainty of the evidence (GRADE)
Risk with conventional therapiesRisk with Duhuo Jisheng decoction

Study population
Clinical effective rate748 per 1,000920 per 1,000 (793–1,000)RR 1.23 (1.06, 1.42)650 (8 RCTs)⊕⊝⊝⊝ Very low
BDM of the lumbar spineThe mean BDM of the lumbar spine was 0MD 0.46 higher (0.24 higher–0.68 higher)330 (4 RCTs)⊕⊕⊝⊝ Low
BGPThe mean BGP was 0MD 0.84 lower (1.69 lower–0)370 (5 RCTs)⊕⊝⊝⊝ Very low
E2The mean E2 was 0SMD 0.49 higher (0.3 higher–0.68 higher)470 (6 RCTs)<⊕⊕⊝⊝ Low

⊕ means high quality, and ⊖ means low quality. These two symbols come from the GRADE system. They are used to classify the certainty of evidence. For a piece of evidence, the more the patient-important outcomes we are confident, the more the symbol “⊕” will be show. The GRADE system classifies the certainty of evidence as follows: high further research is very unlikely to change our confidence in the estimation of effect. Moderate further research is likely to have an important impact on our confidence in the estimation of effect and may change the estimate. Low further research is very likely to have an important impact on our confidence in the estimation of effect and is likely to change the estimate. Very low means any estimate of effect is very uncertain.

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