Review Article
Clinicopathological Significance of Heat Shock Protein (HSP) 27 Expression in Gastric Cancer: A Updated Meta-Analysis
Table 1
Characteristics of studies included in this meta-analysis.
| | Author | Year | Country | Study design | No. of samples | Age | Gender: male (±)
female (±) | HSP27 expression: gastric cancer (±)
adjacent tissue (±)
control (±) | Differentiation: low (±)
high and middle (±) | Lymph node metastasis: metastasis (±)
nonmetastasis (±) | Distant metastasis: metastasis (±)
nonmetastasis (±) | Quality score | | Gastric cancer | Adjacent tissue | Normal tissue |
| | Li et al. | 2010 | China | ROS | 45 | 30 | 20 | 29–70 | 15/8
16/6 | 31/14
8/22 | 9/18
22/27 | 18/11
13/3 | NA | 8 | | Tang et al. | 2009 | China | ROS | 34 | 34 | 34 | 32–84 | NA | 18/16
4/30 | NA | NA | NA | 6 | | Song et al. | 2009 | China | ROS | 41 | NA | NA | 60–77 | NA | NA | 3/8
9/21 | NA | NA | 6 | | Li et al. | 2012 | China | ROS | 48 | NA | 14 | 30–75 | NA | 31/17 | 25/11
6/6 | 29/10
2/7 | 5/1
26/16 | 8 | | Hu et al. | 2015 | China | ROS | 75 | 75 | NA | 23–78 | 35/18
13/9 | 43/32
62/13 | 32/9
16/18 | 32/9
16/18 | NA | 7 | | Wen et al. | 2017 | China | ROS | 20 | NA | NA | 22–86 | NA | NA | 2/2
15/1 | NA | NA | 7 | | Song et al. | 2001 | China | ROS | 54 | NA | NA | 20–83 | NA | NA | 7/10
11/19 | NA | NA | 7 | | Bo et al. | 2003 | China | CSS | 98 | NA | NA | 36–78 | NA | 49/49 | 6/15
39/30 | 20/19
29/30 | NA | 5 | | Lu et al. | 2007 | China | ROS | 68 | 57 | NA | 35–76 | 18/19
14/17 | 32/36
15/42
44/16 | 4/11
28/25 | 10/15
22/21 | NA | 7 | | Shang et al. | 2012 | China | ROS | 60 | 60 | 60 | 33–81 | 31/12
13/4 | 6/54
3/57 | 30/16
6/8 | 30/13
14/3 | 0/3
43/14 | 7 | | Khaldon Bodoor et al. | 2016 | Jordan | ROS | 87 | NA | 16 | 25–98 | NA | 66/21
14/2 | NA | NA | NA | 8 | | Shinsuke Takeno et al. | 2001 | Japan | CSS | 42 | NA | NA | 42–85 | 15/11
7/9 | NA | NA | NA | NA | 6 | | Kapranos | 2002 | Greece | ROS | 86 | NA | 86 | 37–85 | 25/19
29/13 | NA | NA | 48/23
6/9 | NA | 7 |
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