Clinicopathological Significance of Heat Shock Protein (HSP) 27 Expression in Gastric Cancer: A Updated Meta-Analysis

Table 2

The odds ratio between HSP27 expression and clinicopathological feature of gastric cancer.

Clinicopathological features		Heterogeneity
		No. of studies	No. of patients	Pooled OR (95% CI)	PHet	I^2 (%)	P value	Model used
HSP27 expression	GC vs AT	5	173	6.25 (2.88, 13.57)	0.008	71	<0.00001	Random
	GC vs NT	4	159	6.31 (1.10, 36.15)	<0.0001	86	0.04	Random
Differentiation	PD vs HMD	9	270	1.14 (0.52, 2.52)	0.001	69	0.74	Random
Gender	Male vs female	6	231	0.95 (0.62, 1.48)	0.71	0	0.83	Fixed
Lymph node metastasis	N1-3 vs N0	7	289	1.44 (0.66, 3.16)	0.004	69	0.36	Random
Distant metastasis	M1 vs M0	3	96	0.64 (0.10, 4.09)	0.09	58	0.64	Random

Abbreviations: GC, gastric cancer; AT, adjacent tissue; NT, normal tissue; PD, poor differentiation; HMD, high or moderate differentiation; random, random effect model; fixed, fixed effect model; OR, odds ratio; CI, conference interval.