Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 1

Research Article

Statement to an Insufficient Systematic Review on Viscum album L. Therapy

Table 1

Corrections as to risk of bias assessment.

IssueRelevant studiesRiskReview’s assessment [21]Corrected evaluation according to Cochrane Handbook

AErroneous assessment of risk of bias of “random sequence generation (RSQ)[3641]Random sequence generationHigh riskLow risk

BErroneous assessment of risk of bias of “allocation concealment” in six studies[3641]Premature knowledge of allocationHigh riskLow risk

CErroneous assessment of risk of bias of “incomplete outcome data”[4246]Incomplete outcome dataHigh riskHigh risk of bias is not justified

D1Inconsistent evaluation of risk of bias between studies with the same risk[47] vs. [48]Allocation concealmentLow risk, for a study with no advantage of mistletoe [47] vs. high risk, for a study with advantage of mistletoe [48]Equal assessment of risks

D2Inconsistent evaluation of risk of bias between studies with the same risk[47] vs. [44]Incomplete outcome dataLow risk, for a study with no advantage of mistletoe [47] vs. high risk, for a study with advantage of mistletoe [44]Equal assessment of risks

E1Erroneous assessment of risk of bias of “other sources of bias”[47]Other source of biasLow risk, for a study with no advantage of mistletoeHigh risk, as essential criticism has been published [49] towards the Kleeberg publication

E2Erroneous assessment of risk of bias of “other sources of bias”[45, 50, 51]Other source of biasHigh riskLow risk, a in two of the studies [45, 50] significant results were evaluated

E3Erroneous assessment of risk of bias of “other sources of bias”at least 16 studiesOther source of biasUnclear riskLow risk, as “bad reporting quality” is not a defined criterion for assessing the risk of bias according to the Cochrane Handbook

E4Erroneous assessment of risk of bias of “other sources of bias”Other source of biasHigh riskLow risk, as a “multiple testing problem” is not attributable to this study as the only primary endpoint “overall survival” has been proven in a confirmatory test

E5Erroneous assessment of risk of bias of “other sources of bias”[52]Other source of biasHigh riskLow risk, as the individual best supportive care was described in this study

Cochrane Handbook for Systematic Review of Interventions [26].

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