Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 1

Research Article

Mechanisms and Molecular Targets of the Tao-Hong-Si-Wu-Tang Formula for Treatment of Osteonecrosis of Femoral Head: A Network Pharmacology Study

Table 1

The list of active compounds in the THSWT formula.

Chinese nameLatin nameSpeciesFamilyTCMSP IDChemical compoundsOral bioavailability (%)Drug-likeness

Bai-ShaoPaeoniae Radix AlbaPaeonia lactiflora PallRanunculaceaeMOL000211Mairin55.380.78
MOL000358β-sitosterol36.910.75
MOL001359Sitosterol36.910.75
MOL000422Kaempferol41.880.24
MOL000492(+)-catechin54.830.24
MOL00191011α, 12α-epoxy-3β-23-dihydroxy-30-norole-an-20-en-28, 12β-olide64.770.38
MOL001918Paeoniflorgenone87.590.37
MOL001919(3S, 5R, 8R, 9R, 10S, 14S) -3, 17-dihydroxy-4, 4, 8, 10, 14-pentamethyl-2, 3, 5, 6, 7, 9-hexahydro-1H-cyclopenta[a]phenanthrene-15, 16-dione43.560.53
MOL001921Lactiflorin49.120.80
MOL001924Paeoniflorin53.870.79
MOL001925paeoniflorin_qt68.180.40
MOL001928albiflorin_qt66.640.33
MOL001930Benzoyl paeoniflorin31.270.75
Dang-GuiAngelicae Sinensis RadixAngelica sinensis (Oliv.) DielsApiaceaeMOL000358β-sitosterol36.910.75
MOL000449Stigmasterol43.830.76
Tao-RenPersicae SemenPrunus persica (L.) BatschRosaceaeMOL000358β-sitosterol36.910.75
MOL001323Sitosterol alpha143.280.78
MOL0013282,3-didehydro GA7063.290.50
MOL0013292,3-didehydro GA7788.080.53
MOL001339GA11976.360.49
MOL001340GA12084.850.45
MOL001342GA121-isolactone72.700.54
MOL001343GA12264.790.50
MOL001344GA122-isolactone88.110.54
MOL001348Gibberellin 1794.640.49
MOL0013494a-formyl-7alpha-hydroxy-1-methyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid88.600.46
MOL001350GA3061.720.54
MOL001351Gibberellin A44101.610.54
MOL001352GA5464.210.53
MOL001353GA6093.170.53
MOL001355GA6365.540.54
MOL001358Gibberellin 773.800.50
MOL001360GA7787.890.53
MOL001361GA8768.850.57
MOL0013683-O-p-coumaroylquinic acid37.630.29
MOL001371Populoside_qt108.890.20
MOL000296Hederagenin36.910.75
MOL000493Campesterol37.580.71
Shu-Di-HuangRehmanniae Radix PraeparataRehmannia glutinosa LiboschScrophulariaceaeMOL001359Sitosterol36.910.75
MOL000449Stigmasterol43.830.76
Chuang-XiongChuanxiong RhizomaLigusticum chuanxiong HortApiaceaeMOL001359Sitosterol36.910.75
MOL000433Folic acid68.960.71
MOL001494Mandenol42.000.19
MOL002135Myricanone40.600.51
MOL002140Perlolyrine65.950.27
MOL002151Senkyunone47.660.24
MOL002157Wallichilide42.310.71
Hong-HuaCarthami FlosCarthamus tinctorius L.CompositaeMOL000358β-sitosterol36.910.75
MOL000449Stigmasterol43.830.76
MOL000422Kaempferol41.880.24
MOL001771Poriferast-5-en-3beta-ol36.910.75
MOL0026944-[(E)-4-(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene) but-2-enylidene]-2,6-dimethoxycyclohexa-2,5-dien-1-one48.470.36
MOL002680Flavoxanthin60.410.56
MOL002695Lignan43.320.65
MOL002698Lupeol-palmitate33.980.32
MOL002706Phytoene39.560.50
MOL002707Phytofluene43.180.50
MOL002710Pyrethrin II48.360.35
MOL0027126-Hydroxykaempferol62.130.27
MOL002714Baicalein33.520.21
MOL002717qt_carthamone51.030.20
MOL0027196-Hydroxynaringenin33.230.24
MOL002721Quercetagetin45.010.31
MOL0027577,8-dimethyl-1H-pyrimido[5,6-g]quinoxaline-2,4-dione45.750.19
MOL002773Beta-carotene37.180.58
MOL002776Baicalin40.120.75
MOL000006Luteolin36.160.25
MOL000953CLR37.870.68
MOL000098Quercetin46.430.28

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