An Anti-Inflammatory Composition of Boswellia serrata Resin Extracts Alleviates Pain and Protects Cartilage in Monoiodoacetate-Induced Osteoarthritis in Rats

Figure 3

LI13019F1 mitigates the harmful effects of proinflammatory cytokines on chondrocytes. (a) The bar diagram shows the effect of an increasing concentration of LI13019F1 on human primary chondrocytes survivability in the presence of IL-1β. The absorbance values obtained in the vehicle control culture wells were considered as 100% cell viability. Each bar presents the data of mean ± SD, n = 4. (b) The bar diagram shows the modulation in intracellular glycosaminoglycan (GAG) content at various concentrations of LI13019F1-treated cells in the presence of IL-1β, as indicated. The amount of GAG present in the 0.2% DMSO-treated cells (vehicle control) was presented as 100 percent. Each bar shows a mean ± SD. n = 4. (c) & (d) the histogram and bar diagram show the efficacy of LI13019F1 in recovering the SOX-9-positive SW1353 human chondrosarcoma cells (in percentage) following the IL-1β induction. Each bar presents a mean ± SD of percent SOX-9-positive cells from three independent experiments. (vs. vehicle control) and (vs. IL-1β treated) indicate significance (), using two-way ANOVA.

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