Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19

Table 4

Genes altered by quercetin, genistein, chrysoeriol, tectorigenin, glabridin, and gallic acid.

Compounds	Genes
Quercetin	SERPIND1; MAPK1; HMOX1; MMP2; PLAT; PON1; PON2; MPO; CCL2; COL1A1; SULT1E1; IL2; IFNG; ODC1; CTSD; GSTM2; AHR; KCNH2; IL1B; EGF; RB1; TP53; SOD1; EGFR; GJA1; AKR1B1; PPARG; VCAM1; MMP3; ACHE; INSR; COL3A1; ADRB2; PRSS1; GSTM1; NQO1; MMP1; ACPP; HSPA5; SELE; PTGDR2; F3; HSP90AA1; CYP3A4; CYP1A2; PTGER3; DPP4; TOP1; CD40LG; JUN; PLAU; ALOX5; AR; F7; THBD; MAOB; XDH; CDK1; BCL2; GSTP1; IL6; GABRA1; TOP2B; NCOA2; SCN5A; FAM213B; RXRA; POR; COX14; MGAM; VEGFA; ACACA
Genistein	MAPK1; GCK; CCL2; SULT1E1; MAPK14; MAPK3; IL1B; CDK2; TP53; EGFR; SERPING1; AKR1B1; CDK1; INS; BCL2; ESR1; FAM213B; LDLR; VEGFA; BTK; PPARG; HMGCR; VCAM1; HPGD; GLB1; PRSS1; NOS2; SELE; PTGDR2; RAB11B; HDAC6; HSP90AA1; KCNJ11; CD40LG; PTGFR; JUN; AR; SYK
Chrysoeriol	MAPK14; CDK2; SERPING1; PPARG; PRSS1; GSK3B; NOS2; PCP4; PTGDR2; HSP90AA1; DPP4; AR; NCOA1; NCOA2; ESR1; FAM213B
Tectorigenin	MAPK14; IL1B; CDK2; CCNA2; SERPING1; PPARG; PRSS1; GSK3B; NOS2; PCP4; PTGDR2; HSP90AA1; ESR2; PTGER3; SPDEF; AR; PAK7; NCOA1; ESR1; FAM213B; RXRA
Glabridin	MAPK14; CDK2; CCNA2; SERPING1; PPARG; ACHE; ADRB2; CHRM1; ADRA1B; PRSS1; GSK3B; NOS2; PCP4; PTGDR2; ESR2; RXRB; AR; PAK7; NCOA1; NCOA2; ESR1; SCN5A
Gallic acid	TOP2B; PGR; PTGDR2; FASN; MGST1; MAOB; TP53; PTPN21; HSP90AA1

These genes were obtained from the TCMSP database and confirmed in the DrugBank database. All gene names were standardized by using the UniProtKB database for Homo sapiens.