Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products

Table 4

Formulas for rheumatoid arthritis in the contemporary clinical guideline and corresponding formulas in the search results.

Syndromes in 2018 guideline	Formulas in 2018 guideline^1	Formulas in ZHYD search^1
(1) Bi syndrome due to wind and coldness^2	Qiang Huo Sheng Shi Tang; Juan Bi tang; Da qin jiao tang.	Qiang Huo Sheng Shi Tang (n = 5).; Related formulas: Da qiang huo tang (n = 8); Qin jiao tang (n = 2).
(2) Bi syndrome due to cold and dampness	Wu tou tang; Gui zhi shao yao zhi mu tang; Ma huang fu zi xi xin tang.	Wu tou tang (n = 35); Gui zhi shao yao zhi mu tang (n = 21)
(3) Bi syndrome due to dampness and heat	Xuan bi tang; Dang gui nian tong tang; Er miao san.	Dang gui nian tong tang (n = 5); Er miao san/wan (n = 7).
(4) Bi syndrome due to phlegm and blood stasis	Shuang he tang.	Related formulas: Si wu tang (n = 21); Wu ji san (n = 12); Er chen tang (n = 5).
(5) Bi syndrome due to blood stasis	Shen tong zhu yu tang; Tao hong yin.	Related formula: He xue san tong tang (n = 4).
(6) Bi syndrome due to deficiency of qi and blood	Huang qi gui zhi wu wu tang; Shi quan da bu tang; Gui pi tang.	Huang qi gui zhi wu wu tang, also called Huang qi wu wu tang (n = 2)
(7) Bi syndrome due to deficiency of liver and kidney	Du huo ji sheng tang; San bi tang.	Du huo ji sheng tang (n = 4); San bi tang (n = 1).
(8) Bi syndrome due to deficiency of qi and yin^3	Si shen jian.	None relevant

¹See supplementary 2 for the Chinese characters. ²Bi syndrome is a broad traditional diagnostic category that includes arthritis, but here it refers to RS. ³This syndrome is for RA with Sjogren syndrome, which often has symptoms of dry eye or dry mouth. ZHYD: Zhong Hua Yi Dian.