Alleviation by Mahuang Fuzi and Shenzhuo Decoction in High Glucose-Induced Podocyte Injury by Inhibiting the Activation of Wnt/β-Catenin Signaling Pathway, Resulting in Activation of Podocyte Autophagy

Figure 5

One of the possible mechanisms of MFSD to alleviate the damage of high glucose to podocytes. In high glucose environment, Wnt/β-catenin signaling pathway is activated, and β-catenin accumulates in cells and finally participates in nuclear transcription of downstream proteins, inhibits transcription and production of p62/SQSTM1, and restricts autophagy. MFSD inhibits the activation of Wnt/β-catenin signaling pathway and prevents the autophagy process from being restricted.