Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer's Disease

Table 1

Pharmacodynamic effect of anti-AD of 7 herbs.

Latin name	Chinese name	Pharmacodynamic effect of anti-AD
Andrographis paniculata	Chuanxinlian	Andrographolide, one of main active component of AP, reduced or eliminated Aβ aggregate and attenuated Aβ neurotoxicity [11, 29, 30]
Coptis chinensis	Huanglian	Berberine and polysaccharide from CC could reduce Aβ-induced toxicity and ameliorate cognitive impairment [12, 31, 32]
Cortex Phellodendri amurensis	Guanhuangbai	The ethanol extract of CPA has the potential protective effect against neurotoxicity induced by Aβ [33]
Lonicera japonica	Jinyinhua	LJ can effectively prevent the cognitive dysfunction induced by Aβ deposition [34]
Houttuynia cordata	Yuxingcao	HC water extract protects cortical neurons against Aβ-induced toxicity [35]
Centella asiatica	Jixuecao	CA extract reduces Aβ level and improves neuronal health [36, 37]
Gardenia jasminoides	Zhizi	GJ extract improves cognitive and memory impairment on Aβ-induced mouse [38]