| Primary investigator [ref] | Indication | Study design | Comparison groups | Number of patients | Dose (drops/day) | Washout (days) | Duration of therapy | Plus NSAID | Published | Comment |
| Meier [17] | RA | db | Placebo, “nothing” | 5, 5, 5 | 3 × 30 | | 2 weeks | Diclo. | No | Pilot study | Eberl et al. [18] | RA | db | Placebo | 20, 17 | 3 × 30 | | 1 year | Diclo. | No | | Schadler [19, 20] | OA | db | Placebo | 15, 15 | 3 × 40 | | 2 × 7 days | Diclo. | Yes | Crossover | Huber [21, 22] | MD | db | Placebo | 18, 20 | 3 × 30 | 1 | 3 weeks | Diclo. | Yes | | Hahn and Hübner-Steiner [23, 24] | MD | db, open | Placebo, indomethacin | 15, 15, 15 | 3 × 30 (40) | | 4 weeks | | Yes | | Speck et al. [25] | MD | db | Placebo | 15, 11, 11, 10 | 3 × 30, dd, hd | | 4 weeks | | No | Various concentrations | Bernhardt et al. [26] | MD | db, open | Placebo, piroxicam | 36, 36, 36 | 3 × 30 | | 4 weeks | | No | | Müller-Faßbender [27] | OA | db | Placebo, Populus extract | 71, 72, 72 | 3 × 40 | 2 | 3 weeks | | No | | Schreckenberger [28] | Epicondylitis | sb | Diclofenac | 16, 15 | 3 × 30 | | 1 week | | No | | Schreckenberger [29, 30] | Epicondylitis | db, sb | Placebo, diclofenac | 15, 15, 15 | 3 × 40 | | 2 weeks | | Yes | | Schadler [19, 20] | OA | sb | Diclofenac | 15, 15 | 3 × 30 | | 3 weeks | | Yes | | Schadler and Kalmbach [31] | MD | sb | Diclofenac | 10/10 | 3 × 30 (40) | | 24 weeks | | No | | Baumann et al. [32] | OA | db | Diclofenac | 52, 56 | 3 × 30 (40) | | 2 weeks | | No | Double-dummy | Herzog et al. [33] | MD | db | Diclofenac | 277, 140 | 3 × 40 | 7 | 4 weeks | Paracet. | No | Double-dummy | Hawel et al. [34–36] | MD | db | Diclofenac | 108, 106 | 3 × 40 | | 3 weeks | | No | Double-dummy | Michael and Sörensen [37] | MD | db | Populus extract | 12, 13 | 3 × 30 (40) | | 4 weeks | | No | | Botzenhardt [38] | RA | sb | Indomethacin | 16, 15 | 3 × 30 | | 3 weeks | Paracet. | No | | Vajda and Kiss-Antal [39] | OA | sb | Iontophoresis | 15, 15 | 2 × 5 mL | | 3 weeks | Paracet. | No | |
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