Effect of Cellgevity® Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine

Table 2

Pharmacokinetic parameters of carbamazepine for the two groups of rats administered carbamazepine plus Cellgevity®, or carbamazepine plus normal saline over a period of 14 days.

Parameters (unit)	Carbamazepine + normal saline	Carbamazepine + cellgevity®
Cmax (µmol/L)	11	20
Tmax (h)	4	4
ke (h^−1)	0.41	0.28
t1/2 (h)	1.7	2.3
AUC0 ⟶ 24 (µmol h/L)	170	347
AUC0 ⟶ ∞ (µmol h/L)	178	375