Multiple Mechanisms of Flaxseed: Effectiveness in Inflammatory Bowel Disease

Table 2

Comparison of mortality rate and DAI of acetic acid-induced colitis in mice.

	Mortality rate (%)		DAI (%)
	Oil	Extract	Oil	Extract
Untreated	58.33 ± 4.23#	50 ± 5.01%	2.17 ± 0.06	2.11 ± 0.03#
150 mg/kg	55 ± 12%	33.33 ± 5%	2.1 ± 0.08	1.17 ± 0.01
300 mg/kg	33.33 ± 6%	25 ± 8%	1.80 ± 0.02	0.71 ± 0.21
500 mg/kg	8.33 ± 5%	33 ± 6%	0.93 ± 0.01	0.97 ± 0.23

Values given are means ± SEM of 3 experiments (n = 12). One-way ANOVA was used for statistical analysis followed by Tukey’s posttest. , ; compared with the untreated group (#); all the drugs were administered intraperitoneally for 7 days. Colitis was induced on the 6^th day with intrarectal administration of 0.1 ml 6% acetic acid. Mice were assessed 24 hrs after induction of colitis. DAI [18] = (weight loss + stool consistency + rectal bleeding)/3; mortality rate = (mice died in a group/total number of mice in that group) × 100. DAI: disease activity index.