Evidence-Based Complementary and Alternative Medicine

Research Article

Multiple Mechanisms of Flaxseed: Effectiveness in Inflammatory Bowel Disease

Table 4

EC₅₀ values of different PDE-subtype inhibitors with and without Fs.Cr pretreatment.


PDE inhibitor
Cilostazol (µM)	Control	+Fs.Cr	+Rolipram	+Zaprinast
EC₅₀	156.3#	0.91	0.15	2.83
CI	76.32 to 319.9	0.35 to 2.35	0.06 to 0.39	1.48 to 5.41
Rolipram (µM)	Control	+Fs.Cr	+Cilostazol (µM)	+Zaprinast
EC50	12.41#	10.34	2.421	1.61
CI	6.42 to 23.98	5.49 to 19.46	1.21 to 4.83	0.96 to 2.70
Zaprinast (µM)	Control	+Fs.Cr	+Rolipram	+Cilostazol
EC50	146.3#	3.59	19.28	0.38
CI	74.45 to 287.4	1.381 to 9.37	11.91 to 31.21	0.15 to 0.96

EC₅₀: effective concentration to produce 50% response; CI: confidence interval; Fs.Cr: aqueous-methanolic crude extract of Flaxseed (70; 30). All concentrations are in µM. ; ; one-way ANOVA was done followed by Tukey’s posttest to compare the significance of means ± SEM of controls with other groups. ^#All treatment groups are compared with Control.