Review Article

The Clinical Effectiveness of Cognitive Behavioral Therapy for Patients with Insomnia and Depression: A Systematic Review and Meta-Analysis

Table 3

Characteristics of included RCTs.

Study IDParticipants (M/F)Age (years)InterventionUnderlying diseaseMedicine used for underlying diseaseControlDuration of treatment (I/C)Time point of assessmentOutcomes

Casault et al. [23]I: 1/19
C: 2/16
I: 56.9 ± 10.8
C: 57.0 ± 9.4
CBT-I (self-administered) weeklyNonmetastatic cancerNoneNo treatment6 weeks/6 weeksWeek 6ISI, HADS-D
Daniel et al. [24]I: 62/13
C: 62/14
I: 32.21 ± 7.18
C: 32.67 ± 7.97
CBT-I, weeklyNoneNoneNo treatment6 weeks/6 weeksWeek 6ISI, BDI
Shan [25]I: 26/18
C: 24/20
I: 54.22 ± 8.39
C: 54.23 ± 8.42
CBT-I, weeklyIschemic strokeAspirin; simvastatinNo treatment4 weeks/4 weeksWeek 4PSQI,SDS
Wang et al. [26]I: 18/25
C: 18/27
I: 57.19 ± 8.51
C: 56.73 ± 8.96
CBT-I, weeklyVarious types of cancerChemotherapy drugsNo treatment4 weeks/4 weeksWeek 4PSQI,SDS
Hou et al. [27]I: 20/31
C: 22/25
I: 54.5 ± 13.8
C: 52.4 ± 14.5
CBT-I, weeklyMaintain hemodialysis (MHD)NoneNo treatment12 weeks/12 weeksWeek 12PSQI, SCL-90
Yang et al. [28]I: 20/30
C: 19/34
I: 56.54 ± 9.97
C: 56.73 ± 11.27
CBT-I (remote-interactive), more than once a weekHypertensionAntihypertensive drugsNo treatment8 weeks/8 weeksWeek 8ISI,PSQI, BDI
Sylvia et al. [29]I: 6/3
C: 5/1
I: 47.22 ± 15.21
C: 51.17 ± 10.65
CBT-I (individual), weeklyPoststroke fatigueMedicine (specific drugs not available)No treatment (waitlist control)8 weeks/8 weeksWeek 8ISI,PSQI,HADS-D
Markus et al. [30]I: 7/10
C: 5/10
I: 57.8 ± 6.6
C: 53.6 ± 10.4
CBT-I, weeklyHearing impairmentNot mentionedNo treatment (waitlist control)7 weeks/7 weeksWeek 8ISI, HADS-D
David et al. [31]I: 20/82
C: 20/82
I: 44.66 ± 11.65
C: 43.75 ± 11.84
CBT-I (web-based), weeklyNoneNoneNo treatment (waitlist control)6 weeks/6 weeksWeek 7ISI,QIDS-CR16
Lancee et al. [32]I: 6/30
C: 7/20
I: 47.47 ± 14.37
C: 49.98 ± 13.71
CBT-I (online), weeklyNoneNoneNo treatment (waitlist control)12 weeks/12 weeksWeek 12ISI, CES-D, adverse event
(1) Lancee et al. [33]I: 4/26
C: 5/25
I: 41.2 ± 14.1
C: 45.1 ± 13.7
CBT-I (online), weeklyNoneNoneNo treatment (waitlist control)12 weeks/12 weeksWeek 12ISI, CES-D
(2) Lancee et al. [33]I: 8/22
C: 5/25
I: 38.5 ± 13.1
C: 45.1 ± 13.7
CBT-I (individual, face to face), weeklyNoneNoneNo treatment (waitlist control)12 weeks/12 weeksWeek 12ISI, CES-D
Lorenz et al. [34]I: 8/21
C: 9/18
I: 41.72 ± 17.31
C: 44.04 ± 20.05
CBT-I (web-based), weeklyNoneNoneNo treatment (waitlist control)6 weeks/6 weeksWeek 6ISI,BDI
Talbot et al.[35]I: 7/22
C :7/9
I: 37.1 ± 10.4
C: 37.3 ± 11.0
CBT-I (individual), weeklyPosttraumatic stress disorder (PTSD)Medicine (specific drugs not available)No treatment (waitlist control)8 weeks/8 weeksWeek 8ISI,BDI
Han and Liu [36]I: 14/17
C: 14/18
I: 37 ± 14
C: 35 ± 14
CBT-I, weeklyNoneNoneZopiclone 3.75~11.25 mg QN8 weeks/8 weeksWeek 8PSQI,SCL-90
Huang et al. [37]I: 35/93
C: 28/85
I: 46.78 ± 13.75
C: 45.49 ± 12.83
CBT-I (group), weeklyNoneNoneZopiclone 3.75~7.5 mg QN8 weeks/8 weeksWeek 8ISI,HAMD
Zhou et al. [38]150/160NoneCBT-I, weeklyNoneNoneEstazolam 1 mg QN6 weeks/6 weeksWeek 6PSQI,SDS
Lin et al. [39]I: 4/16
C: 4/17
I: 46.5 ± 12.5
C: 45.5 ± 12.4
CBT-I (remote-interactive), weeklyNoneNoneBenzodiazepine agonist8 weeks/8 weeksWeek 8ISI,PSQI, HAMD

Note. M: male; F: female; I: intervention; C: control; QN: once a night; MHD: maintain hemodialysis disorder; PTSD: posttraumatic stress; ISI: Insomnia Severity Index; PSQI: Pittsburgh Sleep Quality Index; HAMD: Hamilton Depression Scale; HADS-D: Anxiety and Depression Scale-Depression; BDI: Beck Depression Inventory; SDS: Self-Rating Depression Scale; SCL-90: Symptom Checklist 90; CES-D: Centre of Epidemiological Studies Depression Scale; and QIDS-CR16: Quick Inventory of Depressive Symptomatology—Clinician Rating.