Antimetastatic Potential of Rhodomyrtone on Human Chondrosarcoma SW1353 Cells

<div>Rhodomyrtone inhibited SW1353 cell metastasis by suppressing integrin <svg height="6.1934pt" id="M32" style="vertical-align:-0.2324901pt" version="1.1" viewbox="-0.0498162 -5.96091 13.3963 6.1934" width="13.3963pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M545 106L524 126C493 85 467 65 455 65C438 65 427 113 405 238C448 295 498 362 543 439L533 448L478 435C453 386 423 331 398 295H395C370 404 347 448 282 448C169 448 23 309 23 153C23 54 65 -12 128 -12C203 -12 283 70 339 155H341C360 29 380 -12 411 -12C444 -12 491 11 545 106ZM333 204C265 95 210 54 169 54C137 54 113 96 113 171C113 302 191 405 252 405C301 405 318 306 333 204Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.385,0)"><path d="M219 86C216 168 211 250 206 337C201 410 189 448 163 448C131 448 79 396 43 344L60 322C91 359 110 375 118 375S132 358 136 298C141 238 152 81 155 -12H182C242 62 331 177 390 258C435 321 451 360 451 391C450 424 432 448 408 448C390 448 372 435 366 419C362 410 362 401 366 394C373 383 376 367 376 350C376 283 262 138 221 86H219Z"></path></g></svg><i>β</i>3/FAK/AKT/small Rho GTPases pathway as well as downregulation of MMP-2/9 via ERK and JNK signaling pathway inhibition.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: Antimetastatic Potential of Rhodomyrtone on Human Chondrosarcoma SW1353 Cells 