Evaluation of the Antidiarrheal Activity of Hydromethanol Crude Extracts of Ruta chalepensis and Vernonia amygdalina in Mice

Table 1

Effect of the crude extract of Ruta chalepensis leaves on castor oil-induced diarrheal model in mice.

Group	Onset time of diarrhea (min)	Total # of wet feces in 4 h	Total weight of feces (gm)	% Inhibition of defecation	% Mean fecal output
Control	87.33 ± 29.96	2.67 ± 0.67	1.85 ± 0.24	—	—
Loperamide 3 mg/kg	234.3 ± 3.81	1 ± 0.52	0.55 ± 0.18	62.8	30
CE100 mg/kg	82.8 ± 25	2.3 ± 0.62	1.03 ± 0.25	13.86	56
CE200 mg/kg	93.5 ± 40	3.3 ± 0.84	0.98 ± 0.24	23.6	53
CE400 mg/kg	206.3 ± 31.53	1.3 ± 0.67	0.63 ± 0.11	51.31	34

Note. Values are expressed as mean ± SEM (n = 6), and analysis was performed with one-way ANOVA followed by the Tukey test, . CE = crude extract, and controls received 10 ml/kg of 2% Tween 80 in distilled water. SEM: standard error of the mean and ANOVA: analysis of variance.