Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC-TOF-MS and UHPLC-MS/MS

Table 3

Effects of the extracts and fractions of celery seeds on inhibition of HSC-LX2 cell proliferation (mean ± SD, n = 3).

Group	Fraction	Dose (μg·mL^−1)	OD	Inhibition ratio (%)
Solvent control		—	0.254 ± 0.019	—
Blank control		0	1.021 ± 0.079	—
Model group (TGF-β1)		0.1	3.522 ± 0.178^##	—
BJRG		50	1.116 ± 0.012	73.11 ± 0.87
Aqueous extract of celery seeds		50	3.532 ± 0.227^##	—
		100	3.074 ± 0.131	13.79 ± 2.91
		200	2.537 ± 0.541	30.13 ± 1.02
95% ethanol extract of celery seeds		50	3.602 ± 0.281	—
		100	2.926 ± 0.0526	18.22 ± 1.69
		200	1.717 ± 0.026	55.22 ± 2.44
60% ethanol extract of celery seeds		50	2.123 ± 0.138	42.75 ± 2.21
		100	1.351 ± 0.052	66.42 ± 1.53
		200	1.097 ± 0.022	74.20 ± 2.38
	PP	25	2.598 ± 0.224	28.26 ± 1.29
		50	1.619 ± 0.129	58.21 ± 2.11
		75	1.066 ± 0.023	75.14 ± 1.45
	PE	25	2.893 ± 0.159	19.23 ± 1.32
		50	2.001 ± 0.239	46.55 ± 3.87
		75	1.119 ± 0.312	73.52 ± 2.36
	PB	25	2.956 ± 0.239	17.30 ± 3.13
		50	1.916 ± 0.209	49.24 ± 2.03
		75	1.754 ± 0.241	54.09 ± 1.44
	PW	25	3.369 ± 0.319^##	4.68 ± 0.75
		50	2.889 ± 0.162	19.36 ± 1.72
		75	2.105 ± 0.311	43.36 ± 3.55

Compared with the blank control group (, ); compared with the model group (, ).