Research Article
Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC-TOF-MS and UHPLC-MS/MS
Table 3
Effects of the extracts and fractions of celery seeds on inhibition of HSC-LX2 cell proliferation (mean ± SD, n = 3).
| Group | Fraction | Dose (μg·mL−1) | OD | Inhibition ratio (%) |
| Solvent control | | — | 0.254 ± 0.019 | — | Blank control | | 0 | 1.021 ± 0.079 | — | Model group (TGF-β1) | | 0.1 | 3.522 ± 0.178## | — | BJRG | | 50 | 1.116 ± 0.012 | 73.11 ± 0.87 |
| Aqueous extract of celery seeds | | 50 | 3.532 ± 0.227## | — | | 100 | 3.074 ± 0.131 | 13.79 ± 2.91 | | 200 | 2.537 ± 0.541 | 30.13 ± 1.02 |
| 95% ethanol extract of celery seeds | | 50 | 3.602 ± 0.281 | — | | 100 | 2.926 ± 0.0526 | 18.22 ± 1.69 | | 200 | 1.717 ± 0.026 | 55.22 ± 2.44 |
| 60% ethanol extract of celery seeds | | 50 | 2.123 ± 0.138 | 42.75 ± 2.21 | 100 | 1.351 ± 0.052 | 66.42 ± 1.53 | 200 | 1.097 ± 0.022 | 74.20 ± 2.38 | PP | 25 | 2.598 ± 0.224 | 28.26 ± 1.29 | 50 | 1.619 ± 0.129 | 58.21 ± 2.11 | 75 | 1.066 ± 0.023 | 75.14 ± 1.45 | PE | 25 | 2.893 ± 0.159 | 19.23 ± 1.32 | 50 | 2.001 ± 0.239 | 46.55 ± 3.87 | 75 | 1.119 ± 0.312 | 73.52 ± 2.36 | PB | 25 | 2.956 ± 0.239 | 17.30 ± 3.13 | 50 | 1.916 ± 0.209 | 49.24 ± 2.03 | 75 | 1.754 ± 0.241 | 54.09 ± 1.44 | PW | 25 | 3.369 ± 0.319## | 4.68 ± 0.75 | 50 | 2.889 ± 0.162 | 19.36 ± 1.72 | 75 | 2.105 ± 0.311 | 43.36 ± 3.55 |
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Compared with the blank control group ( , ); compared with the model group ( , ). |