Research Article
Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC-TOF-MS and UHPLC-MS/MS
Table 6
Effects of monomeric compounds on the proliferation of HSC-LX2 cells (mean ± SD, n = 3).
| | Group | Dose (μg·mL−1) | OD | Inhibition ratio (%) |
| | Solvent control | — | 0.164 ± 0.012 | — |
| | Blank control | 0 | 1.210 ± 0.070 | — |
| | Model group(TGF-β1) | 0.1 | 3.325 ± 0.138## | — |
| | BJRG | 60 | 0.939 ± 0.104 | 75.46 ± 2.11 |
| | Apigenin | 15 | 2.746 ± 0.167 | 18.33 ± 1.48 | | 30 | 1.816 ± 0.046 | 47.72 ± 1.93 | | 60 | 1.071 ± 0.107 | 71.32 ± 2.41 |
| | 5-Methoxypsoralen | 15 | 3.337 ± 0.128 | — | | 30 | 3.382 ± 0.130 | — | | 60 | 3.454 ± 0.117 | — |
| | Apiin | 15 | 3.238 ± 0.177## | 2.73 ± 0.06 | | 30 | 2.716 ± 0.184 | 19.26 ± 1.30 | | 60 | 2.349 ± 0.329 | 30.87 ± 1.85 |
| | Rutin | 15 | 3.412 ± 0.193 | — | | 30 | 3.201 ± 0.104## | 3.92 ± 0.57 | | 60 | 2.825 ± 0.184 | 15.81 ± 2.68 |
| | Kaempferol | 15 | 3.462 ± 0.161 | — | | 30 | 3.186 ± 0.252## | 4.38 ± 1.02 | | 60 | 2.629 ± 0.177 | 22.02 ± 3.93 |
| | Luteolin | 15 | 3.329 ± 0.202 | — | | 30 | 3.341 ± 0.175 | — | | 60 | 3.420 ± 0.330 | — |
| | Quercetin | 15 | 3.186 ± 0.268## | 4.39 ± 0.75 | | 30 | 2.337 ± 0.224 | 31.26 ± 2.11 | | 60 | 1.798 ± 0.218 | 48.28 ± 2.74 |
| | Mollugin | 15 | 3.348 ± 0.152 | — | | 30 | 3.350 ± 0.183 | — | | 60 | 3.425 ± 0.159 | — |
| | Butylphthalide | 15 | 3.029 ± 0.249## | 9.36 ± 1.01 | | 30 | 2.366 ± 0.048 | 30.33 ± 2.77 | | 60 | 1.367 ± 0.164 | 61.93 ± 3.51 |
| | Aesculetin | 15 | 2.426 ± 0.245 | 28.44 ± 4.01 | | 30 | 1.979 ± 0.122 | 42.55 ± 3.14 | | 60 | 1.277 ± 0.273 | 64.90 ± 4.21 |
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Compared with the blank control group ( , ); compared with the model group ( , ). |
