Research Article
Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology
Table 3
The major targets of the CHs in the treatment of CRC.
| No. | Target name | Gene symbol | Degree value in the PPI network |
| 1 | RAC-alpha serine/threonine-protein kinase | Akt1 | 23 | 2 | Heat shock protein HSP 90-alpha | HSP90AA1 | 21 | 3 | Transcription factor p65 | RELA | 21 | 4 | Retinoic acid receptor RXR-alpha | RXRA | 20 | 5 | Tumor necrosis factor | TNF | 19 | 6 | Nuclear receptor coactivator 1 | NCOA1 | 19 | 7 | Estrogen receptor | ESR1 | 19 | 8 | Glucocorticoid receptor | NR3C1 | 18 | 9 | Nuclear factor NF-kappa-B p105 subunit | NFKB1 | 16 | 10 | Epidermal growth factor receptor | EGFR | 15 | 11 | Mitogen-activated protein kinase 8 | MAPK8 | 15 | 12 | Proto-oncogene c-Fos | FOS | 15 | 13 | Interleukin-6 | IL6 | 15 | 14 | G1/S-specific cyclin-D1 | CCND1 | 14 | 15 | Cytochrome P450 1A1 | CYP1A1 | 13 | 16 | Retinoblastoma-associated protein | RB1 | 13 | 17 | Myc protooncogene protein | MYC | 13 | 18 | Androgen receptor | AR | 13 | 19 | Caspase-8 | CASP8 | 12 | 20 | Caspase-3 | CASP3 | 12 | 21 | Amyloid beta A4 protein | APP | 12 | 22 | Cytochrome c oxidase subunit 2 | MT-CO2 | 11 | 23 | Peroxisome proliferator-activated receptor gamma | PPARG | 11 | 24 | Vascular endothelial growth factor A | VEGFA | 11 | 25 | Peroxisome proliferator-activated receptor alpha | PPARA | 11 |
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