Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology

Table 3

The major targets of the CHs in the treatment of CRC.

No.	Target name	Gene symbol	Degree value in the PPI network
1	RAC-alpha serine/threonine-protein kinase	Akt1	23
2	Heat shock protein HSP 90-alpha	HSP90AA1	21
3	Transcription factor p65	RELA	21
4	Retinoic acid receptor RXR-alpha	RXRA	20
5	Tumor necrosis factor	TNF	19
6	Nuclear receptor coactivator 1	NCOA1	19
7	Estrogen receptor	ESR1	19
8	Glucocorticoid receptor	NR3C1	18
9	Nuclear factor NF-kappa-B p105 subunit	NFKB1	16
10	Epidermal growth factor receptor	EGFR	15
11	Mitogen-activated protein kinase 8	MAPK8	15
12	Proto-oncogene c-Fos	FOS	15
13	Interleukin-6	IL6	15
14	G1/S-specific cyclin-D1	CCND1	14
15	Cytochrome P450 1A1	CYP1A1	13
16	Retinoblastoma-associated protein	RB1	13
17	Myc protooncogene protein	MYC	13
18	Androgen receptor	AR	13
19	Caspase-8	CASP8	12
20	Caspase-3	CASP3	12
21	Amyloid beta A4 protein	APP	12
22	Cytochrome c oxidase subunit 2	MT-CO2	11
23	Peroxisome proliferator-activated receptor gamma	PPARG	11
24	Vascular endothelial growth factor A	VEGFA	11
25	Peroxisome proliferator-activated receptor alpha	PPARA	11