Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Fig 6

Research Article

Role of Chrysophanol in Epithelial-Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt-3-Dependent Pathway

Figure 6

A summary diagram outlines the working mechanisms of oridonin in FaDu cells. (a) Chrysophanol caused ROS accumulation. (b) Chrysophanol downregulated the expressions of Wnt-3 and nuclear translocations of NF-κB/p65 or β-catenin. On the other hand, chrysophanol also attenuated EMT formation and cell migration.

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