Role of Chrysophanol in Epithelial-Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt-3-Dependent Pathway

<div>A summary diagram outlines the working mechanisms of oridonin in FaDu cells. (a) Chrysophanol caused ROS accumulation. (b) Chrysophanol downregulated the expressions of Wnt-3 and nuclear translocations of NF-<i>κ</i>B/p65 or <i>β</i>-catenin. On the other hand, chrysophanol also attenuated EMT formation and cell migration.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 6

Figure 6: Role of Chrysophanol in Epithelial-Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt-3-Dependent Pathway 