Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p

Figure 1

Effect of curcumin on apoptosis, cell cycle, migration, and invasion of HCT-116/L-OHP cells. (a) Structure of curcumin. (b) Effect of L-OHP on proliferation inhibition rate of HCT-116 cells and HCT-116/L-OHP cells (mean ± SEM, n = 3). (c) Effect of curcumin on survival rate of HCT-116 cells and HCT-116/L-OHP cells at different concentrations (mean ± SD, n = 3). (d) Flow cytometry for the effect of curcumin on apoptosis of HCT-116/L-OHP cells. (e) Effect of curcumin on the cell cycle of HCT-116/L-OHP by flow cytometry. (f) Migration effect of curcumin on HCT-116/L-OHP cells after 48 h incubation. (g) Invasion effect of curcumin on HCT-116/L-OHP cells after 48 h incubation. The data were presented in mean ± SD, n = 3 versus control group, , , .

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