Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p

Figure 3

MiR-409-3p can specifically bind to ERCC1 and inhibit the mRNA expression of ERCC1. (a)-(b) The expression of miR-409-3p and miR-138 in different group. (c)–(e) ERCC1, P-gp, and survivin mRNA expression in miR-409-3p or miR-138 siRNA treatment group. (f)-(g) Double luciferase reporter gene test and immunoprecipitation test were used to compare the binding ability of miR-409-3p/miR-138 and ERCC1. (h) Bioinformatics analysis of the binding of miR-409-3p to ERCC1. The data were presented in mean ± SD, n = 3 versus HCT-116 group, , versus control group, , , .

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