Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide-Induced Cardiotoxicity in Rats

Figure 5

Histopathological changes in the heart tissue treated with crude extract and aqueous fraction. (a) Normal control group (normal structures of the heart). (b) Cyclophosphamide control group (congestion, degeneration of myocardial tissue, and necrosis). (c) Enalapril control group (mild necrosis). (d) Crude extract at 100 mg/kg (hypertrophy). (e) Crude extract at 200 mg/kg (edema and focal necrosis). (f) Crude extract at 400 mg/kg (edema). (g) Aqueous fraction at 100 mg/kg (edema and congestion). (h) Aqueous fraction at 200 mg/kg (edema and slight degeneration of myocardial tissue).

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