Research Article
Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide-Induced Cardiotoxicity in Rats
Table 1
Grouping and dosing of rats used in experiments (AQ: aqueous fraction; CE: crude extract; EA: ethyl acetate fraction).
| | Treatment groups | Dose |
| | Treatment groups (CE and AQ) | | | Normal control (0.9% normal saline) | 0.5 mL/100 g | | Cyclophosphamide (CP) control | 200 mg/kg | | Standard control—enalapril (EN) | 10 mg/kg | | Crude extract (CE 100) | 100 mg/kg | | Crude extract (CE 200) | 200 mg/kg | | Crude extract (CE 400) | 400 mg/kg | | Aqueous fraction (AQ 100) | 100 mg/kg | | Aqueous fraction (AQ 200) | 200 mg/kg |
| | Treatment groups (EA) | | | Normal control (2% DMSO) | 0.5 mL/100 g | | Cyclophosphamide (CP) control | 200 mg/kg | | Standard control—enalapril (EN) | 10 mg/kg | | Ethyl acetate fraction (EA 100) | 100 mg/kg | | Ethyl acetate fraction (EA 200) | 200 mg/kg |
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