Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide-Induced Cardiotoxicity in Rats
Table 2
Effects of crude extract and aqueous fraction on body weight, heart weight, and heart-to-body weight ratio.
Group
Dose
Relative weight changes (g)
Heart weight (g)
Heart-to-body wt. ratio (×10−3)
NC
NS (0.5 mL/100 g)
+6.0 ± 5.24
0.91 ± 0.01
2.77 ± 0.06
CP
200 mg/kg
−101.33 ± 7.88
1.17 ± 0.04
5.53 ± 0.17
EN
10 mg/kg
−65.8 ± 5.07##
0.89 ± 0.02###
3.69 ± 0.28###
100 mg/kg
−68.5 ± 5.63#
1.01 ± 0.02##
3.71 ± 0.15###
CE
200 mg/kg
−75.0 ± 5.02
0.99 ± 0.01##
3.86 ± 0.19###
400 mg/kg
−76.0 ± 6.22
0.88 ± 0.02###
3.74 ± 0.19###
AQ
100 mg/kg
−66.33 ± 4.07###
0.87 ± 0.01###
4.16 ± 0.11###
200 mg/kg
−64.33 ± 3.40###
0.85 ± 0.01###
3.98 ± 0.11###
Results are expressed as mean ± SEM (n = 6). when compared with normal control; , and when compared with CP control. AQ: aqueous fraction; CP: cyclophosphamide; CE: crude extract; EN: enalapril; NC: normal control; NS: normal saline.
