Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide-Induced Cardiotoxicity in Rats

Table 3

Effects of ethyl acetate fraction on body weight, heart weight, and heart-to-body weight ratio.

Group	Dose	Relative weight changes (g)	Heart weight (g)	Heart-to-body wt. ratio (×10^−3)
NC	2% DMSO (0.5 mL/100 g)	+8.0 ± 1.24	0.58 ± 0.04	2.16 ± 0.13
CP	200 mg/kg	−125.0 ± 1.23	0.81 ± 0.03	5.37 ± 0.23
EN	10 mg/kg	−93.17 ± 4.03^#	0.54 ± 0.03^###	3.67 ± 0.07^###
EA	100 mg/kg	−95.83 ± 10.56^#	0.70 ± 0.03	3.77 ± 0.17^###
	200 mg/kg	−95.33 ± 10.66^#	0.69 ± 0.02	3.63 ± 0.06^###

Results are expressed as mean ± SEM (n = 6). when compared with normal control; and when compared with CP control. EA: ethyl acetate fraction; CP: cyclophosphamide; CE: crude extract; EN: enalapril; NC: normal control; DMSO: dimethyl sulfoxide.