Integrated Analyses of lncRNA and mRNA Profiles Reveal Characteristic and Functional Changes of Leukocytes in Qi-Deficiency Constitution and Pi-Qi-Deficiency Syndrome of Chronic Superficial Gastritis

Figure 6

The common differential lncRNAs-mediated regulation of the common differential genes in two case populations. (a) Network to detail the possible direct binding of lncRNAs to the mRNAs of common genes. 70 lncRNAs could directly bind to the mRNAs of 11 genes. Nodes with red font labels indicate a consistent upregulation expression in both case populations. Nodes with green font denote a consistent downregulation expression in both case populations. Node size depends on the number of edges, and the number is shown near the corresponding node. The “”-labeled lncRNAs were novel in this work. (b) Expression clustering and subcellular location analyses for the 70 common lncRNAs capable of directly binding to the mRNAs of common genes. Prediction of subcellular location involves exosome, ribosome, nucleus, cytosol, and cytoplasm. Red or green labels indicate that the corresponding lncRNA is consistent upregulation or downregulation expression in both case populations. (c) Network to detail the possible interactions between the common lncRNAs and the common genes-coded proteins. 17 lncRNAs could directly bind to 7 proteins. Node size depends on the number of edges, and the number is shown near the corresponding node. (d) Interaction network analysis of the common genes.

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