The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency

Figure 6

Treatment with Zuogui. (a) Treatment with Zuogui brought the metabolomic pattern of the plasma of perimenopausal rats towards that of rats at the initial phase of perimenopause before treatment. (b) Zuogui even brought the metabolomic profile of the plasma of perimenopausal rats (green) towards that of rats that had not entered the perimenopause at the age of 6 months old (red). (c) Zuogui brought the metabolic state of perimenopausal rats towards that at younger ages. Red for rats that had not entered the perimenopausal period, green for perimenopausal rats, and purple for Zuogui-treated rats. (d) Zuogui modulates many metabolites in the energy metabolism at moderately higher levels. The exceptions were succinate and acetoacetate, which are elevated to significantly higher levels in the plasma. ; ; .

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