In Vitro Antiosteoporosis Activity and Hepatotoxicity Evaluation in Zebrafish Larvae of Bark Extracts of Prunus jamasakura Medicinal Plant

Figure 4

Hepatotoxicity assay in zebrafish larvae. (a) Schematic diagram of hepatotoxicity assay in zebrafish. (b) Treatment with DMSO did not show liver cell death. (c) Tamoxifen treatment induced liver cell death (red arrow). (d) No liver cell death was observed at concentration of 200 μg/ml of water extract. (e) No liver cell death was observed at concentration of 200 μg/ml of ethanolic extract. (f) No liver cell death was observed at concentration of 200 μg/ml of methanolic extract.

(a)

(b)

(c)

(d)

(e)

(f)