Increment of Lysosomal Biogenesis by Combined Extracts of Gum Arabic, Parsley, and Corn Silk: A Reparative Mechanism in Mice Renal Cells

Figure 3

Photomicrographs of histological sections of mice renal cortex by hematoxylin and eosin (HE х400). Normal control (a): normal renal cortex can be seen with normal glomerular tuft (G), normal proximal convoluted tubules (P) with vesicular nuclei (arrow), normal distal convoluted tubules with vesicular nuclei (D). Amikacin group (b) shows atrophied vacuolated cytoplasmic epithelium of the distal convoluted tubules with pyknotic nuclei (D), atrophied vacuolated cytoplasmic epithelium of the proximal convoluted tubules with pyknotic nuclei (P), interstitial proliferated tissue (arrow), lobulation of the glomerular tuft (G), abundance of dense acidophilic hyaline casts (arrowhead), and cellular debris in tubular lumina (stars). Gum Arabic group (c) shows the proximal convoluted tubules (P) that are lined with high cuboidal cells with rounded vesicular basal nuclei (arrow) and deeply acidophilic cytoplasm, the distal convoluted tubules (D) have wider lumina and are lined with cubical cells with rounded vesicular central nuclei and paler acidophilic cytoplasm, and there are still few cellular debris (stars) and hyaline casts (arrowhead). Parsley group (d) shows normal glomerular tuft (G), some normal proximal convoluted tubules (P) with vesicular nuclei (arrow), and normal distal convoluted tubules (D); some of them show cellular vesicular debris (stars). Corn silk group (e) shows normal proximal convoluted tubules (P) with vesicular nuclei (arrow) and narrow lumen, normal distal convoluted tubules (D), with abundant vesicular nuclei (arrow), and few cellular debris. Combination group (f): the renal cortex shows malpighian renal corpuscle (arrow) containing glomerulus (G) and nondilated Bowman’s space (B), normal proximal convoluted tubules (P) with vesicular nuclei (arrowhead) and narrow lumina, normal distal convoluted tubules (D), and no cellular debris or hyaline casts present. A reclaim of renal architecture is obvious.

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