Efficacy and Safety of Tongning Gel for Knee Osteoarthritis: A Multicentre, Randomized, Double-Blinded, Parallel, Placebo-Controlled, Clinical Trial

Table 2

Comparison of WOMAC scores between two groups before and after intervention.

0 weeks

1 week

2 weeks

3 weeks

TNG (n = 431)

PC (n = 144)

value

TNG (n = 431)

PC (n = 144)

value

TNG (n = 431)

PC (n = 144)

value

TNG (n = 431)

PC (n = 144)

value

Pain

183.61 ± 64.86

177.36 ± 66.92

0.3215

159.63 ± 61.09

167.19 ± 65.53

0.2074

132.44 ± 57.51

163.13 ± 68.96

<0.0001

101.45 ± 58.94

158.03 ± 75.01

<0.0001

Stiffness

47.87 ± 31.53

46.76 ± 32.48

0.7165

42.45 ± 29.47

43.99 ± 31.86

0.5939

35.00 ± 26.41

41.90 ± 31.49

0.0188

27.67 ± 23.71

40.42 ± 31.74

<0.0001

Function

579.88 ± 195.62

555.01 ± 202.97

0.1913

505.09 ± 187.64

523.15 ± 202.33

0.3275

415.13 ± 176.35

504.24 ± 211.74

<0.0001

329.11 ± 183.62

486.81 ± 227.44

<0.0001

Total

811.35 ± 272.16

779.13 ± 281.19

0.2230

707.17 ± 261.09

734.33 ± 279.83

0.2890

582.58 ± 246.31

709.26 ± 293.42

<0.0001

458.23 ± 254.54

685.26 ± 315.79

<0.0001

Plus-minus values are means ± SD unless otherwise noted. Comparison between TNG group and PC group by ANOVA.