Research Article

Efficacy and Safety of Tongning Gel for Knee Osteoarthritis: A Multicentre, Randomized, Double-Blinded, Parallel, Placebo-Controlled, Clinical Trial

Table 3

Comparison of decreased value from baseline between two groups.

Mean ± SD (95% CI)Between group difference, mean ± SD (95% CI) value
TNG (n = 431)PC (n = 144)

Pain
1 week23.98 ± 26.24 (21.49, 26.46)10.17 ± 23.42 (6.32, 14.03)13.80 ± 2.46 (8.97, 18.64)<0.001
2 weeks51.16 ± 40.27 (47.35, 54.97)14.24 ± 32.57 (8.87, 19.60)36.93 ± 3.70 (29.65, 44.20)<0.001
3 weeks82.16 ± 54.24 (77.02, 87.29)19.33 ± 47.85 (11.45, 27.22)62.82 ± 5.07 (52.86, 72.79)<0.001

Stiffness
1 week5.42 ± 8.99 (4.57, 6.27)2.76 ± 9.28 (1.24, 4.29)2.66 ± 0.87 (0.94, 4.37)0.0015
2 weeks12.87 ± 15.46 (11.41, 14.33)4.85 ± 11.63 (2.94, 6.77)8.02 ± 1.41 (5.26, 10.78)<0.001
3 weeks20.19 ± 18.76 (18.42, 21.97)6.34 ± 16.09 (3.69, 8.99)13.85 ± 1.75 (10.43, 17.28)<0.001

Physical function
1 week74.79 ± 71.12 (68.05, 81.52)31.86 ± 58.40 (22.24, 41.48)42.93 ± 6.56 (30.04, 55.81)<0.001
2 weeks164.74 ± 121.07 (153.28, 176.20)50.77 ± 91.85 (35.64, 65.90)113.97 ± 11.02 (92.33, 135.61)<0.001
3 weeks250.77 ± 162.20 (235.41, 266.13)68.19 ± 137.81 (45.49, 90.89)182.58 ± 15.06 (153.00, 212.16)<0.001

Total
1 week104.18 ± 97.59 (94.94, 113.42)44.80 ± 84.95 (30.81, 58.79)59.38 ± 9.10 (41.50, 77.27)<0.001
2 weeks228.77 ± 166.06 (213.05, 244.50)69.86 ± 129.27 (48.57, 91.16)158.91 ± 15.18 (129.10, 188.72)<0.001
3 weeks353.12 ± 224.1 7 (331.90, 374.35)93.87 ± 196.14 (61.56, 126.18)259.25 ± 20.94 (218.13, 300.38)<0.001

Comparison between TNG group and PC group by ANOVA.