Review Article

Nonalcoholic Fatty Liver Disease: Pathogenesis and Treatment in Traditional Chinese Medicine and Western Medicine

Table 1

Basic methods used in NAFLD differentiation treatment.

TypesChinese medicinal herbsEffect

Chai Hu Li Zhong Tang [52]Bupleurum, Scutellaria, ginger Pinellia, Codonopsis, Atractylodes, Poria, turmeric, Zhigancao, ginger, and jujube↓TG, TC, LDL-C, AST, ALT, and insulin
↑HDL-C; activating AMPKα

Ganshutang decoction [53]Coptidis chinensise, pinellia ternata, trichosanthes kirilowii, rhizoma curcumae longae concisa, and aralia taibaiensis↓TG and LDL-C↑HDL-C and MDA Improving fatty degeneration and membrane fluidity of hepatocellular mitochondria. Protecting the structure and function of liver sieve and hindering lipid peroxides from being generated

Ruangan compound [54]Selfheal, alga, desmodium, oyster and polygonum multiflorum↓MDA; ↑SOD Correcting unbalanced oxidation and antioxidation; hindering hepatic stellate cells from being activated and their proliferation and prevent extracellular matrixes from anomalous deposition

Ganzheng compound [55]Radix bupleuri, salvia miltiorrhiza, rhizoma alismatis, and pinellia ternata
↓TNF-α; ↑Adiponectin
↓CYP2E1 Reverse hepatic steatosis and inflammation

Aromatic fat-reducing drug [56]Agastache stem, hypericum japonicum thunb, five leaf akebia fruit, serissa foetida comm., white peony root, herba artemisiae scopariae, angelica sinensis, and poria cocos↓ALT, AST, TG and TC

Ahome-made spleen-invigorating and dampness-eliminating decoction [57]Radix pseudostellariae, poria cocos, bighead atractylodes rhizome, radix glycyrrhizae, pinellia ternata, and dried tangerine or orange peel↓TC, TG, ALT, AST and GGT
A good liver-protecting and antilipemic effect

Fuzilizhong decoction [58]Ginseng radix et rhizoma, Rhizoma atractylodis macrocephalae, Radix glycyrrhizae preparata, Zingiberisrhizoma, Aconiti Lateralis radix praeparataLimiting pathological changes; lowering the content of blood lipid
Improving liver function and decreasing liver index

A compound made from panax japonicus, salvia miltiorrhiza, and hawthorn [59]Panax japonicus, salvia miltiorrhiza, and hawthornAntioxidant activity

A phlegm-dissolving and stasis-removing herb [60]Processed rhizoma pinelliae, Fujian rhizoma alismatis, alga, salvia miltiorrhiza, curcuma wenyujin, stir-baked radix bupleuri with vinegar, radix et rhizoma rhei, semen cassiae, roasted bighead atractylodes rhizome, and raw astragalus↓TC, TG, FFA, ALT, and AST; promoting the upregulated expression of LXRα mRNA and ABCA1 to limit liver pathological changes

TangGanJian [61]White paeony root, angelica sinensis, Bupleurumchinense, wolfiporia cocos, atractylodes macrocephala koidz, artemisia capillaris thunb, polygonum cuspidatum sieb. et zucc, Schisandra chinensis (Turcz.) baill, and coptis chinensis franch↓TNF-α, IL-6, IL-1β, CRP
↑GSH-PX and SOD; modulating the inflammatory response and the capacity of oxidative stress

Shugan-Jianpi Recipe [62]Chai hu, chen pi, chuan xiong, Xiang fu, zhi qiao, Bai shao, and gan cao↓IL-1β, IL-6, and TNF-α
↓p38 MAPK/NF-κBmRNA and a protein