Antileukemic Effect of Palladium Nanoparticles Mediated by White Tea (Camellia sinensis) Extract In Vitro and in WEHI-3B-Induced Leukemia In Vivo

Table 3

Histopathological scoring of spleen in mice with induced leukemia, or in healthy (negative) control animals, after 28 days of treatment as stated.

Animal group	Leukemic cells %	Nonleukemic cells %	Score	Indication
Negative control	0.0 ± 0.0	100.0 ± 0.0	0	Normal
Induced leukemia control	85.51 ± 1.4a	14.49 ± 0.7	4	Severe change
50 mg/kg [email protected]	19.65 ± 0.45b	80.35 ± 0.55	1	Mild change
100 mg/kg [email protected]	18.2 ± 0.25b	81.8 ± 0.15	1	Mild change
Blank-NPs	72.25 ± 2.1a	27.75 ± 1.5	4	Severe change
5 mg/kg ATRA	13.50 ± 0.16b	86.50 ± 0.26	1	Mild change

Values are mean ± SD, n = 4 sections. a - compared with negative control; b– compared with induced leukemia control by one-way ANOVA followed by Tukey’s B-test. Sections were stained with H&E.