Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 4

Research Article

Antileukemic Effect of Palladium Nanoparticles Mediated by White Tea (Camellia sinensis) Extract In Vitro and in WEHI-3B-Induced Leukemia In Vivo

Table 4

Bcl-2, Bax, and cytochrome-C mRNA measured and normalized by GAPDH gene by RT-qPCR in spleen from healthy (negative) control mice or mice with induced leukemia after 28 days of treatment as stated.

mRNAControlLeukemiaBlank NPs (100 mg/kg)Pd@W.tea-NPs (50 mg/kg)Pd@W.tea-NPs (100 mg/kg)ATRA (5 mg/kg)

Bcl-212.5 ± 0.1133.01 ± 1.1531.23 ± 0.7525.25 ± 0.2521.12 ± 0.4416.98 ± 1.1
Bax14.07 ± 1.711.34 ± 1.011.55 ± 0.3525.24 ± 0.2031.10 ± 0.1742.10 ± 2.2
Cyt-C12.0 ± 1.158.60 ± 0.759.25 ± 0.2521.54 ± 0.3026.45 ± 0.0534.05 ± 2.1

Values are mean ± SD relative to GAPDH (loading control) measured by densitometry using ImageJ 148-JDK 6 software for n = 3 mice per group, each measured in triplicate. and by one-way ANOVA followed by Tukey’s B-test.

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