Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products

Table 1

Description of drug interactive effects analysed using the combination index method.

Range of combination index (CI)	Description
<1.0	Very strong synergism
0.10–0.30	Strong synergism
0.30–0.70	Synergism
0.70–0.85	Moderate synergism
0.85–0.90	Slight synergism
0.90–1.10	Nearly additive
1.10–1.20	Slight antagonism
1.20–1.45	Moderate antagonism
1.45–3.30	Antagonism
3.30–10	Strong antagonism
>10	Very strong antagonism

[25].