Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products

Table 2

Effect of AME, PAE, and CAPE on the heart rate of normotensive rats.

Time (h)		50 mg/kg	100 mg/kg	150 mg/kg
AME
0		400.17 ± 8.40	422.56 ± 14.14	432.67 ± 20.00
4		408.61 ± 12.71^ns	399.06 ± 13.34^ns	400.78 ± 13.58^ns
8		408.39 ± 65.88^ns	404.89 ± 14.19^ns	410.67 ± 8.67^ns
24		410.39 ± 18.00^ns	423.50 ± 20.01^ns	403.78 ± 7.72^ns
PAE
0		415.00 ± 2.13	415.00 ± 2.13	415.28 ± 3.98
4		410.89 ± 4.82^ns	415.56 ± 6.26^ns	413.56 ± 2.70^ns
8		407.67 ± 2.31^ns	406.11 ± 3.16^ns	414.89 ± 2.61^ns
24		422.11 ± 4.42^ns	439.33 ± 22.46^ns	408.39 ± 6.59^ns
CAPE		CAPE 1	CAPE 2	CAPE 3
0		424.44 ± 9.22	430.00 ± 7.00	418.78 ± 9.85
4		346.66 ± 5.33	339.00 ± 1.73	311.89 ± 3.11
8		413.89 ± 5.39^ns	416.33 ± 11.18^ns	407.44 ± 6.48^ns
24		394.45 ± 14.89^ns	423.89 ± 10.39^ns	406.89 ± 11.50^ns

Values are recorded as mean ± SEM, n = 6. Comparison of hours of treatment to the zero hour: ns: ; ; one-way ANOVA followed by Dunnett’s multiple comparisons test.