Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products
Table 2
Effect of AME, PAE, and CAPE on the heart rate of normotensive rats.
Time (h)
50 mg/kg
100 mg/kg
150 mg/kg
AME
0
400.17 ± 8.40
422.56 ± 14.14
432.67 ± 20.00
4
408.61 ± 12.71ns
399.06 ± 13.34ns
400.78 ± 13.58ns
8
408.39 ± 65.88ns
404.89 ± 14.19ns
410.67 ± 8.67ns
24
410.39 ± 18.00ns
423.50 ± 20.01ns
403.78 ± 7.72ns
PAE
0
415.00 ± 2.13
415.00 ± 2.13
415.28 ± 3.98
4
410.89 ± 4.82ns
415.56 ± 6.26ns
413.56 ± 2.70ns
8
407.67 ± 2.31ns
406.11 ± 3.16ns
414.89 ± 2.61ns
24
422.11 ± 4.42ns
439.33 ± 22.46ns
408.39 ± 6.59ns
CAPE
CAPE 1
CAPE 2
CAPE 3
0
424.44 ± 9.22
430.00 ± 7.00
418.78 ± 9.85
4
346.66 ± 5.33
339.00 ± 1.73
311.89 ± 3.11
8
413.89 ± 5.39ns
416.33 ± 11.18ns
407.44 ± 6.48ns
24
394.45 ± 14.89ns
423.89 ± 10.39ns
406.89 ± 11.50ns
Values are recorded as mean ± SEM, n = 6. Comparison of hours of treatment to the zero hour: ns: ;; one-way ANOVA followed by Dunnett’s multiple comparisons test.