Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products
Table 4
Effect of CAPE and nifedipine on liver and kidney function in ethanol/sucrose-induced hypertension in SD rats.
Parameter
Dose of combined product (mg/kg)
Nifedipine (0.5 mg/kg)
Negative control
Normal control
50 CAPE 1
100 CAPE 1
75 CAPE 2
ALP (U/L)
135.3 ± 7.88
152.9 ± 11.09
134.7 ± 31.23
—
149.5 ± 24.82
95.27 ± 4.54
Total protein (g/L)
63.62 ± 0.85
67.44 ± 1.13
66.86 ± 1.52
71.65 ± 1.55
66.76 ± 2.60
69.30 ± 0.80
Albumen (g/L)
31.80 ± 0.84
29.46 ± 0.63
32.28 ± 1.21
32.87 ± 0.90
31.38 ± 1.34
31.53 ± 0.57
AST (U/L)
158.9 ± 14.58
155.5 ± 16.47
145.3 ± 10.54
168.7 ± 4.615
148.5 ± 15.45
152.0 ± 11.69
ALT (U/L)
41.20 ± 1.62
41.33 ± 2.40
38.50 ± 4.11
31.75 ± 1.63
40.13 ± 4.72
31.17 ± 2.69
GGT (U/L)
6.0 ± 0.0
6.0 ± 0.0
6.0 ± 0.0
6.0 ± 0.0
6.0 ± 0.0
6.0 ± 0.0
TBIL (µmol/L)
3.94 ± 0.25
4.90 ± 0.41
4.54 ± 0.22
9.18 ± 0.14
9.74 ± 0.39
11.77 ± 0.29
Urea (mmol/L)
6.91 ± 0.58
6.99 ± 0.40
7.08 ± 0.47
—
7.78 ± 0.32
8.54 ± 0.33
Creatinine (µmol/L)
88.44 ± 2.57
88.13 ± 2.77
96.02 ± 3.13
—
83.84 ± 3.77
98.82 ± 2.00
Na (mmol/L)
143.6 ± 0.39
143.7 ± 0.70
144.4 ± 0.55
142.9 ± 0.47
143.3 ± 1.07
143.2 ± 0.69
K (mmol/L)
4.92 ± 0.18
5.43 ± 0.07
5.21 ± 0.18
5.86 ± 0.29
5.65 ± 0.43
5.72 ± 0.14
Cl (mmol/L)
102.9 ± 0.64
104.0 ± 0.76
105.1 ± 0.76
100.2 ± 0.91
102.4 ± 0.39
101.6 ± 1.57
Values are expressed as mean ± SEM (n = 5). as compared to the normal control (one-way ANOVA with Dunnett’s multiple comparison post hoc test). ALP: alkaline phosphatase; T: total; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT- γ: glutamyltransferase; Na sodium; K: potassium; Cl: chloride.
