Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products

Table 5

Effect of 50, 75, and 100 mg/kg CAPE and nifedipine on urine content in ethanol/sucrose-induced hypertension in SD rats.

Parameter	Combined extract (mg/kg)			0.5 mg/kg nifedipine	HC	NC
	50 CAPE 1	75 CAPE 2	100 CAPE 1
Leukocyte	Trace	Trace	Trace	Trace	Trace	Trace
Urobilinogen	Trace	Trace	Trace	Trace	Trace	Trace
Bilirubin	Negative	Negative	Negative	Negative	Negative	Negative
Blood	Negative	Negative	Negative	Negative	Negative	Negative
Nitrite	Negative	Negative	Negative	Negative	Negative	Negative
Ph	8.00 ± 0.13	8.50 ± 0.00	7.83 ± 0.31	7.58 ± 0.30	7.75 ± 0.25	7.13 ± 0.13
SG	1.01 ± 0.00	1.01 ± 0.00	1.02 ± 0.00	1.02 ± 0.00	1.01 ± 0.00	1.08 ± 0.06
Protein	++	++	++	++	+++	++
Glucose	Negative	Negative	Negative	Negative	Negative	Negative
Ketones	Negative	Negative	Negative	Negative	Negative	Negative

Values are expressed as mean ± SEM (n = 5). SG: specific gravity; HC: negative control; NC: normal control.