Mode of Action of Shan-Zhu-Yu (Cornus officinalis Sieb. et Zucc.) in the Treatment of Depression Based on Network Pharmacology

Figure 6

Docking conformation of active ingredients and potential targets. Telocinobufagin and NR3C1 (a); beta-sitosterol and Bax (b). The secondary structure of the green region is random coils, near which small molecules are bound; Bcl-2 (c); beta-sitosterol and caspase-3 (d). The cyan and brown parts are subunit p17 and subunit p12 domains, respectively. The red part is the two key amino acid residues, His121 and 163Cys, in the active center of caspase-3.

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