Research Article

Mode of Action of Shan-Zhu-Yu (Cornus officinalis Sieb. et Zucc.) in the Treatment of Depression Based on Network Pharmacology

Table 2

Enriched genes in the biological processes.

Description valueEnriched genes

G protein-coupled amine receptor activity3.9410–15ADRB2, CHRM3, ADRA1A, CHRM2, ADRA2A, ADRB1, ADRA2C, ADRA1D
Neurotransmitter receptor activity3.5810–09CHRM3, CHRM1, CHRM2, CHRNA2, OPRM1, GABRA1, ADRB1
Steroid hormone receptor activity7.5810–09PGR, NR3C2, RXRA, NR3C1, AR, PPARG
Nuclear receptor activity1.6510–07PGR, RXRA, NR3C1, AR, PPARG
Transcription factor activity, direct ligand regulated sequence-specific DNA binding1.6510–07PGR, RXRA, NR3C1, AR, PPARG
G protein-coupled neurotransmitter receptor activity3.6410–07CHRM3, CHRM2, OPRM1, ADRB1
Protein heterodimerization activity8.3010–07ADRA1A, ADRA1B, BCL2, BAX, JUN, RXRA, ADRA2A, ADRB1, PPARG, ADRA2C
Hormone binding2.8710–06CHRM3, CHRNA2, NR3C1, AR, ACHE
Anion: cation symporter activity4.3110–06SLC6A4, SLC6A2, SLC6A3
Acetylcholine receptor activity4.3110–06CHRM3, CHRM2, CHRNA2
Catecholamine binding4.3110–06ADRB2, ADRA2A, ADRA2C
Ammonium ion binding9.1910–06CHRM3, CHRNA2, SLC6A4, ACHE
Adrenergic receptor binding1.3210–05ADRA2A, ADRB1, ADRA2C
Nuclear receptor binding1.5810–05NCOA2, RXRA, NCOA1
Phosphatidylinositol phospholipase C activity1.8710–05CHRM3, CHRM1, CHRM5
Neurotransmitter: sodium symporter activity2.2010–05SLC6A4, SLC6A2, SLC6A3
Phospholipase C activity3.8710–05CHRM3, CHRM1, CHRM5
Chloride transmembrane transporter activity5.4410–05SLC6A4, GABRA1, SLC6A2, SLC6A3
Channel activity6.5710–05SCN5A, KCNH2, CHRNA2, OPRM1, GABRA1, BCL2, BAX
Passive transmembrane transporter activity6.6810–05SCN5A, KCNH2, CHRNA2, OPRM1, GABRA1, BCL2, BAX