Review Article

A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis

Table 2

Functions of potential target genes based on KEGG analysis.

IdTerm valueQ valueGene

hsa04933Age-rage signaling pathway in diabetic complications9.74E − 168.41E − 14MMP2/BCL2/CCL2/COL3A1/SELE/IL6/MAPK1/MAPK14/MAPK8/NOS3/PIM1/THBD/F3/JUN/TNF/VCAM1/VEGFA
hsa05418Fluid shear stress and atherosclerosis1.86E − 148.03E − 13MMP2/BCL2/CCL2/TP53/SELE/GSTM1/HMOX1/IFNG/MAPK14/MAPK8/NQO1/NOS3/THBD/PLAT/JUN/TNF/VCAM1/VEGFA
hsa05215Prostate cancer1.01E − 092.90E − 08AR/BCL2/CDK2/TP53/EGFR/GSK3B/IGF1R/MAPK1/EGF/MMP3/PLAT/PLAU
hsa04020Calcium signaling pathway5.20E − 091.12E − 07HTR2A/ADRA1A/ADRA1B/ADRB2/DRD1/EGFR/PRKACA/CHRM1/CHRM2/CHRM3/CHRNA7/NOS2/NOS3/PTGER3/PPP3CA
hsa04657IL-17 signaling pathway9.60E − 091.66E − 07CCL2/GSK3B/IFNG/IL6/MMP1/MAPK1/MAPK14/MAPK8/MMP3/JUN/TNF
hsa01522Endocrine resistance1.50E − 082.16E − 07MMP2/BCL2/TP53/EGFR/ESR2/IGF1R/MAPK1/MAPK14/MAPK8/PRKACA/JUN
hsa04926Relaxin signaling pathway2.73E − 083.37E − 07MMP2/COL3A1/EGFR/MMP1/MAPK1/MAPK14/MAPK8/PRKACA/NOS2/NOS3/JUN/VEGFA
hsa04659Th17 cell differentiation3.81E − 084.11E − 07AHR/IFNG/IL2/IL6/MAPK1/MAPK14/MAPK8/RXRA/RXRB/PPP3CA/JUN
hsa04066HIF-1 signaling pathway4.62E − 084.43E − 07BCL2/EGFR/HMOX1/IGF1R/IFNG/IL6/MAPK1/NOS2/NOS3/EGF/VEGFA
hsa04080Neuroactive ligand-receptor interaction5.74E − 084.96E − 07HTR2A/ADRA1A/ADRA1B/ADRA2A/ADRA2C/ADRB2/OPRD1/DRD1/GABRA1/NR3C1/CHRM1/CHRM2/CHRM3/OPRM1/CHRNA7/ADCYAP1/PTGER3/F2
hsa04151PI3K-Akt signaling pathway1.06E − 078.33E − 07BCL2/CDK2/TP53/EGFR/GSK3B/MET/IGF1R/IL2/IL6/MAPK1/CHRM1/CHRM2/NOS3/PIK3CG/EGF/RBL2/RXRA/VEGFA
hsa05142Chagas disease (American trypanosomiasis)2.59E − 071.86E − 06CCL2/IFNG/IL2/IL6/MAPK1/MAPK14/MAPK8/NOS2/JUN/TNF
hsa01521EGFR tyrosine kinase inhibitor resistance2.92E − 071.94E − 06BCL2/EGFR/GSK3B/MET/IGF1R/IL6/MAPK1/EGF/VEGFA
hsa05219Bladder cancer3.88E − 072.39E − 06MMP2/TP53/EGFR/MMP1/MAPK1/EGF/VEGFA
hsa04022cGMP-PKG signaling pathway4.76E − 072.74E − 06ADRA1A/ADRA1B/ADRA2A/ADRA2C/ADRB2/KCNMA1/PDE3A/OPRD1/MAPK1/NOS3/PIK3CG/PPP3CA
hsa04915Estrogen signaling pathway5.25E − 072.83E − 06MMP2/BCL2/CTSD/EGFR/ESR2/MAPK1/PRKACA/OPRM1/NOS3/PGR/JUN
hsa04668TNF signaling pathway6.25E − 073.18E − 06CCL2/SELE/IL6/MAPK1/MAPK14/MAPK8/MMP3/JUN/TNF/VCAM1
hsa05202Transcriptional misregulation in cancer1.51E − 067.20E − 06TP53/CCNA2/MET/IGF1R/IL6/MPO/PPARG/RXRA/RXRB/MMP3/PLAT/PLAU
hsa05144Malaria1.58E − 067.20E − 06CCL2/SELE/MET/IFNG/IL6/TNF/VCAM1
hsa04660T cell receptor signaling pathway3.06E − 061.32E − 05GSK3B/IFNG/IL2/MAPK1/MAPK14/MAPK8/PPP3CA/JUN/TNF