Review Article

A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis

Table 3

Summary of the possible mechanism of YFSJF in intervention of PF.

Chinese medicineIngredientsGenePathway

Hedysarum multijugum maxim/Panax notoginseng (burk.) F. H. Chen ex C. Chowi/Mulberry barkQuercetinADRB2/EGFR/PRKACA/NOS2/NOS3/PTGER3Calcium signaling pathway
CCL2/GSK3B/IFNG/IL6/MMP1/MAPK1/MAPK14/MMP3/JUN/TNFIL-17 signaling pathway
AHR/IFNG/IL2/IL6/MAPK1/MAPK14/RXRA/JUNTh17 cell differentiation
BCL2/EGFR/HMOX1/IGF1R/IFNG/IL6/MAPK1/NOS2/NOS3/EGF/VEGFAHIF-1 signaling pathway
BCL2/CDK2/TP53/EGFR/GSK3B/IGF1R/IL2/IL6/MAPK1/NOS3/PIK3CG/EGF/RBL2/RXRA/VEGFAPI3K-Akt signaling pathway
CCL2/SELE/IL6/MAPK1/MAPK14/MMP3/JUN/TNF/VCAM1TNF signaling pathway
GSK3B/IFNG/IL2/MAPK1/MAPK14/JUN/TNFT cell receptor signaling pathway

Hedysarum Multijugum MaximKaempferolADRA1B/PRKACA/CHRM1/CHRM2/NOS2/NOS3/PPP3CACalcium signaling pathway
GSK3B/MMP1/MAPK14/MAPK8/JUN/TNFIL-17 signaling pathway
MAPK14/MAPK8/PPP3CA/JUNTh17 cell differentiation
BCL2/HMOX1/IGF1R/NOS2/NOS3HIF-1 signaling pathway
BCL2/CDK2/GSK3B/IGF1R/CHRM1/CHRM2/NOS3/PIK3CGPI3K-Akt signaling pathway
SELE/MAPK14/MAPK8/JUN/TNF/VCAM1TNF signaling pathway
MAPK14/MAPK8/PPP3CA/JUN/TNFT cell receptor signaling pathway

Fritillariae Thunbrgii Bulbus/Panax Notoginseng (Burk.) F. H. Chen Ex C. Chowi/Mulberry barkBeta-sitosterolHTR2A/ADRA1A/ADRA1B/ADRB2/DRD1/PRKACA/CHRM1/CHRM2/CHRM3/CHRNA7/NOS2Calcium signaling pathway
GSK3B/MAPK14/JUNIL-17 signaling pathway
MAPK14/JUNTh17 cell differentiation
BCL2/NOS2HIF-1 signaling pathway
BCL2/CDK2/GSK3B/CHRM1/CHRM2/PIK3CGPI3K-Akt signaling pathway
MAPK14/JUNTNF signaling pathway
GSK3B/MAPK14/JUNT cell receptor signaling pathway

Hedysarum Multijugum Maxim7-O-MethylisomucronulatolHTR2A/ADRA1A/ADRA1B/ADRB2/DRD1/PRKACA/CHRM1/CHRM2/CHRM3/NOS2/NOS3Calcium signaling pathway
GSK3B/MAPK14IL-17 signaling pathway
MAPK14/RXRA/RXRBTh17 cell differentiation
NOS2/NOS3HIF-1 signaling pathway
CDK2/GSK3B/CHRM1/CHRM2/NOS3/RXRAPI3K-Akt signaling pathway
MAPK14TNF signaling pathway
GSK3B/MAPK14T cell receptor signaling pathway

Panax Notoginseng (Burk.) F. H. Chen Ex C. ChowiStigmasterolHTR2A/ADRA1A/ADRA1B/ADRB2/PRKACA/CHRM1/CHRM2/CHRM3/CHRNA7/NOS2/NOS3Calcium signaling pathway
RXRATh17 cell differentiation
NOS2/NOS3HIF-1 signaling pathway
CDK2/CHRM1/CHRM2/NOS3/RXRAPI3K-Akt signaling pathway