Kang-Xian Pills Inhibit Inflammatory Response and Decrease Gut Permeability to Treat Carbon Tetrachloride-Induced Chronic Hepatic Injury through Modulating Gut Microbiota

Figure 4

KX treatment changed the diversity and abundance of gut microbiota in the CHI mouse model: (a) the Shannon index was lower in the Model group as compared to the Control and KX groups; (b) the Venn diagram indicates the differential numbers of OTUs in each group; (c) PCoA score based on weighted UniFrac metrics was different in each group; (d) system clustering tree of gut microbiota based on weighted UniFrac metrics indicates the different beta diversity of gut microbiota in each group; (e) KX treatment changed the microbial community at the phylum level (bar plot); (f) at the genus level, KX treatment increased the relative abundances of Lactobacillus, Bacteroides, and Akkermansia and decreased the relative abundances of Ralstonia, Alloprevotella, and Lachnoclostridium in the CHI mouse model, the relative abundance of Enterococcus increased in the Model group, and KX treatment did not affect the relative abundance of Enterococcus in the CHI mouse model. Control, Model, and KX groups (n = 6 per group). Data are presented as mean ± SD. ; .

(a)

(b)

(c)

(d)

(e)

(f)