Kang-Xian Pills Inhibit Inflammatory Response and Decrease Gut Permeability to Treat Carbon Tetrachloride-Induced Chronic Hepatic Injury through Modulating Gut Microbiota

Figure 5

KX treatment did not affect the pathological changes after the depletion of gut microbiota. (a, b) KX treatment did not affect the body weight and liver index in CHI model mice after depleting the gut microbiota. (c) H&E staining indicated that KX treatment did not affect the inflammatory cell infiltration and cellular swelling of hepatocytes after depleting the gut microbiota. Black arrows indicate the inflammatory cell infiltration. Red arrows indicate the cellular swelling of hepatocytes. (d, f) Masson staining indicated that KX treatment did not affect the deposition of collagen in the liver after depleting the gut microbiota. (e, g) Immunostaining indicated that KX treatment did not affect the level of α-SMA in the liver after depleting the gut microbiota (100x). Control, Antibiotics, and Antibiotics + KX groups (n = 10 per group). Data are presented as mean ± SD. ^## compared with the Control group.

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